Fill a large pot with water and add salt. Bring the water to a boil and add in pasta. Cook pasta according to the package instructions until almost al dente, about 2 minutes less than what is on the package. Drain, then dump the pasta back into the cooking pot and toss with a little butter to keep it from sticking.
Preheat the oven to 350° Fahrenheit. Use butter or non-stick cooking spray to coat a 9x13-inch baking dish (3 quart).
In a small bowl, mix together the breadcrumbs, 3 tablespoons melted butter, and seasoned salt. Set aside.
Melt one stick of butter over medium high heat in a large saucepan, but don't allow it to brown. Whisk in the flour to combine, stir for about a minute. Whisking constantly, slowly pour in milk in a thin stream. Then repeat with the half and half in the same manner. Whisk until smooth.
Whisk in garlic powder, ground mustard, pepper, and nutmeg. Continue stirring until the sauce is simmering and starts to thicken, this will take 6-8 minutes. You will know the sauce is ready when it coats the back of a wooden spoon and you can draw a line in it with your finger.
Reduce the heat down to low and slowly add the cheddar cheese, stir until it is completely melted. Add in the gruyere cheese and mix until melted. You should have a smooth sauce. Remove from heat.
Pour the white sauce over the cooked pasta noodles and stir until it is all coated. Add in the shredded white cheddar cheese, mix well. Add salt and pepper to taste.
Pour the cheesy pasta into the reserved baking pan, smoothing out the top. Sprinkle on Panko topping and bake for 20 minutes. To make the top golden brown, put the pan under the broiler for 2-3 minutes, but pay close attention to it.
Let cooked Mac and cheese set for 10 minutes, then enjoy!